Most Beautiful 2000: With her girl-next-door looks and laid-back charm, it's no surprise that the Georgia belle graced three World's Most Beautiful covers (1991, 2000 and 2005) – a PEOPLE record. In 1993, The New York Times gushed about the Pretty Woman star, writing, "Her skin is as clear as one of those High Sierra streams where the rare golden trout still swim."
Now: How does the actress, 48, keep her famous smile healthy and bright? With baking soda! In general, the busy mom of three has little time for a more complicated beauty routine. "I'm happy if I have on moisturizer and ChapStick," she told InStyle.