At the end of Grey's second season, Heigl's character tries to save her heart-patient boyfriend Denny, but he abruptly dies after proposing. Heigl receives a Golden Globe nomination for Best Supporting Actress in a Series for her heartbreaking performance. "For me in this industry, I think it helped people to see me as more than just a face or a body, which was very gratifying," she tells New York's Daily News.
Kelley, 25, proposes to Heigl, 27, in Venice Beach, Calif., the same place where they shot the video. "It's ridiculously big," Heigl tells Cosmopolitan of her three-carat, pear-cut diamond engagement ring. "See, I'm really shallow. I was like 'Sure, I'll marry you!'" To top off her engagement, Grey's Anatomy is nominated for 11 Emmy awards, including Outstanding Drama Series. In August, the cast takes home the award for Outstanding Casting.
The actress lands the cover of Cosmopolitan magazine. "This is huge for me. I've always read Cosmo," Heigl tells the AP. "It feels sort of like an out-of-body experience, like it's happening to someone else." In the magazine, she bashes Hollywood's obsession with diets. "I don't condone obesity, but I don't think we all need to be a f---ing size two. It's a ridiculous goal," she tells the magazine. "You know what's important? Living well and not being consumed with eating boring salads you hate. Eat Brie, and have a glass of red wine!"
Heigl slams costar Isaiah Washington when he calls fellow cast member T.R. Knight a "faggot" at the Golden Globes. "I'm sorry, that did not need to be said, I'm not okay with it…T.R. is my best friend. I will throw down for that kid," she tells Access Hollywood. Days later, Knight appears on Ellen DeGeneres' talk show and says the incident forced him to come out. Weeks later, when the cast wins for Outstanding Performance by an Ensemble in a Drama Series at the Screen Actors Guild Awards, Washington misses the ceremony because he sought counseling for his remarks.
Heigl helps Pedigree raise awareness for dog adoption and shelters, with a goal to raise $250,000 for the American Humane Association. "They built a big glass, doghouse enclosure on Times Square that I got to sit in with six, six sheltered dogs and it was really fun," Heigl tells ABC News. "I have four dogs…I really can't imagine my life any other way. And I'm just so grateful that Pedigree cares as much as I do."
Heigl drops out of Grey's contract talks "because I wanted to treat myself with the respect I was not getting from them," Heigl says in a statement. "No matter how unhappy I am about their decision to respond to this publicly, I continue to be passionate about and committed to this character." And her passion pays off with an Emmy nomination for Best Supporting Actress. That May, Heigl also makes her first appearance in PEOPLE's Most Beautiful issue, later lending her looks to sportswear brand Nautica for their first women's fragrance.
Heigl wins her first Emmy for Best Supporting Actress in a Drama Series at the 2007 Emmy Awards. Astonished that she beat Grey's costars Sandra Oh and Chandra Wilson, Heigl mouths, "S---!" and says, "My own mother told me I didn't have a shot in hell of winning tonight." But Heigl thanks her mom in the end, "This is because of you. I wouldn't want to be here without you."
Heigl, 29, exchanges vows with musician Josh Kelley, 27, in scenic Park City, Utah. The private reception is witnessed by Grey's costars T.R. Knight – who tells PEOPLE it was "incredible and beautiful" – and Sandra Oh, as well as Private Practice star Kate Walsh. Taking place in a small, private tent at the Stein Eriksen Lodge, the nuptials last about 30 minutes in an area decked out in white flowers and white candles.
Heigl appears on the cover of Vanity Fair, where she discusses her take on the relationship (dubbed "Gizzie") between her Grey's character Izzie and George (played by T.R. Knight). "I don’t really know Izzie very well right now. She’s changed a lot. I’m trying to figure her out and keep her real," she says of the controversial pairing which has upset many of the show's loyal fans. "It was a ratings ploy. It was absolutely something that shocked people; it wasn’t predictable, and people didn’t see it coming."
In the romantic comedy 27 Dresses, her first film since the massive success of Knocked Up, Heigl (pictured with costar James Marsden) plays Jane, an accommodating, self-sacrificing heroine, who has walked down the aisle (as a bridesmaid) an overwhelming 27 times. Variety says Heigl is "an engaging actress with a flair for physical comedy and self-effacing humor...immensely appealing."
BIOGRAPHY (top to bottom): ABC; Eric Charbonneau/Wireimage; Jamie McCarthy/WireImage; GALE ADLER/ABC; John Shearer/WireImage; Jeffrey Mayer/WireImage; Twentieth Century FOX