Following a frustrating first-half of the season (which found Izzie having an affair with her dead fiancé), Grey's Anatomy fans rally around Heigl's performance as a cancer-stricken Izzie. Addressing reports that Izzie will die because she has intentions of ditching Grey’s for her film career, Heigl denies the claims and calls the Grey's set "one of my favorite places to be."
Heigl returns to movie romance in The Ugly Truth as an uptight TV producer who gets lessons in love from her chauvinistic coworker (played by 300 stud Gerard Butler). The Scottish actor sings her praises, calling Heigl "the sexiest, smartest, sassiest, funniest actress out there."
Heigl announces that she and Kelley are adopting a baby girl named Naleigh from Korea. "I wanted to tell everybody so you don't think I stole a Korean baby," she jokes on Ellen of Naleigh – a nickname for Nancy Leigh, named after Heigl's mother Nancy and sister Margaret Leigh.
After months of speculation, Heigl leaves her post as Izzie Stevens on Grey's Anatomy. "I am done," she proclaims on the cover of EW. The actress reveals that she decided to leave the ABC hit because of her family, not her burgeoning movie career. "[Motherhood] changed my desire to work full-time," she says.
After costarring with Ashton Kutcher in Killers, Heigl teams with another big-screen hunk, Josh Duhamel, for Life As We Know It, about two strangers left to raise their best friends' daughter. "My experience as Holly in this movie was my experience as Katie in real life," she tells InStyle of filming while caring for daughter Naleigh. "There's this thing where, as a new mother, you're just constantly going, Am I doing this right?"
BIOGRAPHY (top to bottom): Everett; Cheyenne Ellis/AP; Courtesy EW; Warner Bros; Ramey