After dating since September 2002, Moore and Roddick call it quits during her visit to New York City to see Roddick play in the U.S. Open. "Not watching much tennis at all these days," she tells the Associated Press after the breakup. "It used to be that I couldn't be by myself," she tells PEOPLE, "and now I've come to savor it."
Moore plays a Bible-thumping mean girl in the indie flick Saved!. "I think Saved! was the beginning for me," she tells Elle. "It was the start of people saying, 'Hey, maybe she's a serious actress. Maybe she's in it for the long haul.' And once you have that feeling, doing work you're really proud of, you want more of it."
Moore launches Mblem, a line of knit T-shirts with lyrics from her favorite songs placed subtly on the shirt. "I never really had an aspiration to be a fashion guru," Moore tells WWD. "I have always been a fan of fashion, but in no way would I have ever considered myself a designer. I'm a real jeans and T-shirt girl, and I couldn't find the exact shirts I liked, so I decided to do something of my own."
Moore attends the Creative Artists Agency's Back to School event with Scrubs star Zach Braff, and the two stars begin dating. In February 2006, Moore guest-stars as the love interest of Braff on a pair of episodes for Scrubs. Was it awkward working with her boyfriend? "No," she tells PEOPLE. "It was totally comfortable, because everyone knows me, and they know that we're together."
Moore stars as an American Idol-type contestant in the movie American Dreamz. "Mandy is frigging talented," director Paul Weitz tells Entertainment Weekly. But unlike her character "She's got her looks in perspective," he says.
On New Year's Eve in Miami, Moore catches up with ex Wilmer Valderrama and has a reunion with old friend Adam "DJ AM" Goldstein, who was once engaged to Nicole Richie. Moore and Goldstein begin dating but call it quits after two months.
Moore admits going through a bout of depression to Jane magazine: "A few months ago I felt really low, really sad – depressed for no reason." Although her recent hush-hush breakup with Braff – who also came out about his struggle with depression – coincides with her blues, it wasn't the main reason behind it, says Moore, who soon moves on with musician Greg Laswell.
After appearing in February's Because I Said So with Diane Keaton, Moore returns to music with her first album since 2003's Coverage, Wild Hope. It's also the only album that Moore insisted on writing her own material: "I am aware enough to know I haven't had a ton of musical success – and music is my first love," she tells Seventeen. "It speaks volumes about who I am...It's so vulnerable." But the multitasking star isn't giving up on film with July's License to Wed costarring The Office's John Krasinski.
Moore lends her speaking and singing voice to animated film Tangled, starring as Rapunzel opposite Zachary Levi, who voices Flynn Ryder. "As soon as I heard that Disney was making another animated film and it was the story of Rapunzel, I'm like, 'I'm in,'" she tells the Pittsburgh Post Gazette. "Just the idea that it can mean to kids what [Disney] movies meant to me as a kid is the coolest thing ever."
BIOGRAPHY (top to bottom): United Artists/Everett; Getty; LAURIE WIERZBICKI/BEImages; Everett; LIMELIGHT; Bauer Griffin; Courtesy of Seventeen Magazine; Ahmad Elatab/Tom Meinelt/Splash News Online; Kevin Winter/Getty