The Friday Night Lights star, 30, tied the knot with fiancée Kiele Sanchez, 36, on Saturday, the actor's rep confirms to PEOPLE.
The couple got engaged in December 2011, a source confirmed to PEOPLE at the time.
Gilford – who played quarterback Matt Saracen on the hit series – costarred with Sanchez, who has appeared on several shows, including Lost and The Glades, in the 2010 TV movie Matadors.
Gilford most recently starred in the canceled series The Mob Doctor.
With reporting by OLIVER JONES