On Sunday, the actress, 54, tied the knot with her fiancé of two years, investment banker Todd Morgan, at a private ceremony in Malibu, Calif., her rep confirms to PEOPLE.
Arquette, the elder sister of actors David Arquette and Patricia Arquette, is best known for her role in Pulp Fiction and recently guest-starred on Girls and Ray Donovan.
Her previous three marriages, all of which ended in divorce, were to movie director Tony Greco, composer James Newton Howard and restaurateur John Sidel – with whom she has an 18-year-old daughter, Zoe Blue.
Speaking last year to the Huffington Post about balancing work and relationships, Arquette said, "It's always about accepting the other person – who they are and what they do. I love to work and I love my partnership, but I really do need both."