The 52-year-old actress has made her first public appearance since news broke that she and Gere, 64, were calling it quits after 11 years of marriage.
On Tuesday night, Lowell attended the 19th annual Artwalk NY gala in downtown New York City. Dressed in a floral dress, black trench coat and strappy heels, she arrived solo to the charity event, which benefits the Coalition for the Homeless.
Lowell was a cochair for the benefit, alongside Alec and Hilaria Baldwin and model Coco Rocha. Interestingly, Gere was listed as the honorary chair for the event, although he was not in attendance.
In late September, a friend of the couple confirmed to PEOPLE that Gere and Lowell had separated. The two, who have a 13-year-old son, Homer, had reportedly been living apart for some time, with Gere staying at their property in Bedford, N.Y. Lowell, meanwhile, remained at their mansion in North Haven, N.Y.
"They'll do everything possible to keep things amicable and put their child first," the pal added.