01:20 PM EDT 05/07/2009

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Christina Applegate

Christina Applegate's New Lease on Life | Christina Applegate

Christina Applegate's New Lease on Life

Originally posted 04/29/2009 08:20AM

She has an "angel" of a boyfriend, Dutch bass player Martyn Lenoble, "who loves me from head to toe." She has a cozy Malibu beach house that she calls "the best thing I've ever done for myself." And, after a very public battle with breast cancer that has given her a gratifying "feeling of purpose," Christina Applegate has a new lease on life.

"I used to be really shy but I started to come into my own in my late 20s and early 30s," Applegate, 37, tells PEOPLE in the cover interview for the annual Most Beautiful issue. "Now I'm not afraid to speak up in a room full of people and be a part of the conversation."

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Christina Applegate: 2009 for Finding Happiness | Christina Applegate

Christina Applegate: 2009 Is for Finding Happiness

Originally posted 01/14/2009 04:05PM

After surviving the death of her former boyfriend and a battle with breast cancer last year, Christina Applegate has a new outlook for 2009.

"It's about finding happiness and joy, as if it were water and I was a person dying in a desert. You have to search for that," Applegate tells PEOPLE.

The actress, who was nominated for a Golden Globe for her role on ABC's Samantha Who?, told PEOPLE at Sunday's awards ceremony that getting through last year wasn't easy: "You can't get any darker than I went."

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Jennifer Esposito Finds Christina Applegate a 'Huge Inspiration' | Christina Applegate, Jennifer Esposito

Health

Jennifer Esposito Finds Christina Applegate a 'Huge Inspiration'

Originally posted 11/18/2008 09:50AM

As Christina Applegate's outspoken best friend on the ABC sitcom Samantha Who?, Jennifer Esposito says of her costar's brave battle with breast cancer, "We can take a lesson from her."

"She's a huge inspiration," Esposito, 35, told PEOPLE at Monday's 8th annual 24 Hour Plays on Broadway, where writers, directors and actors like herself pulled off six original short plays all in 24 hours.

"She never stopped once to say, feel sorry for me. She doesn't look down and doesn't look to the side. She just looks forward and keeps going," said Esposito of Applegate.

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Christina Applegate Is 'Ready to Hug Again'

Health

Christina Applegate Is 'Ready to Hug Again'

Originally posted 10/10/2008 08:30AM

Christina Applegate has been bravely outspoken about her battle with breast cancer. But, the Samantha Who? star reveals, she wasn't always so forthcoming.

"I went back to work for about five weeks right after the second surgery," Applegate tells Ellen DeGeneres on Friday's show. She adds, "I didn't tell anyone [about the diagnosis]."

Actually, she did share the news with a few members of her inner circle.

"I told my make-up and hair people and people that are really close to me ...," she explains. "I had a protection wall [on set], so that no one was pushing me."

The 36-year-old was diagnosed with an early form of breast cancer earlier this year. She is now cancer free after undergoing a double mastectomy.

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Health

Applegate 'Lost It' When She Met Her Surgeon

Originally posted 09/29/2008 01:45PM



It was a delayed reaction to having heard her medical diagnosis – that she had breast cancer – that made Christina Applegate cry, she says.

With October being Breast Cancer Awareness Month, the Samantha Who? star, 36, spoke candidly with Oprah Winfrey on a special installment of The Oprah Winfrey Show set to air Tuesday. On it, Applegate discusses her recent radical mastectomy.

"So you just made the decision that you were gonna let both go," Winfrey asks the actress, in reference to the decision to have both breasts removed.

"Yep. I was just gonna let them go," says Applegate, who then says, when asked if she cried, "You know, I – at first I didn't. And then when I met with my doctor and I told him that was my decision and he brought the surgeon in and it was like the flood gates just opened up and I – I lost it.

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Christina Applegate: Feeling Good Is What Life's About | Christina Applegate

Primetime Emmy Awards 2008

Christina Applegate: Feeling Good Is What Life's About

Originally posted 09/21/2008 08:25PM

Appearing at her first award show since her breast-cancer diagnosis and treatment this summer, Christina Applegate took to the Emmy red carpet Sunday night and declared, "It's a great day … I've got a pretty dress on and lipstick, and [it's] something I haven't done in two months."

Speaking to E! host Ryan Seacrest, the Samantha Who? star, 36 – in a Reem Acra silk organza, jacquard-draped gown – said, "It really feels good to be here ... That's what life's all about." 


Addressing what she's been through (which includes a double mastectomy), Applegate said, "Things happen, and you have to sit back and really, really embrace your life."

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Christina Applegate Returns to Samantha Who? | Christina Applegate

Christina Applegate Returns to Samantha Who? Set

Originally posted 09/15/2008 01:45PM

Christina Applegate has returned to work, her rep confirms to PEOPLE, as filming on her ABC comedy Samantha Who? resumed Monday in Los Angeles.

The actress underwent a double mastectomy in July, after being diagnosed with breast cancer. The surgery was a success, and Applegate, 36, says she's cancer free.

Applegate subsequently appeared on the Sept. 5 Stand Up to Cancer telethon, and is expected to present at the Primetime Emmy Awards on Sept. 21. She is also nominated as lead actress in a comedy series.

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Christina Applegate Presenting at Emmys | Christina Applegate

Primetime Emmy Awards 2008

Christina Applegate Presenting at Emmys

Originally posted 09/11/2008 12:35PM

Christina Applegate, who underwent a double mastectomy after being diagnosed with breast cancer, will make a high-profile public appearance as one of the presenters at the Emmy Awards, PEOPLE has learned.

Applegate, 36, who says she is now cancer free following the surgery, also is nominated for an Emmy for lead actress in a comedy series for Samantha Who? on ABC.

Other presenters to be announced Thursday are Lauren Conrad, Kiefer Sutherland, Candice Bergen, David Boreanaz, Wayne Brady and Jimmy Kimmel.

The 60th Primetime Emmy Awards air at 8 p.m. Sept. 21 on ABC.

Credit: Bryan Bedder/Getty; Munawar Hosain/Getty
Kelly Ripa: Christina Applegate Inspired Me | Christina Applegate, Kelly Ripa

Health

Kelly Ripa: Christina Applegate Inspired Me

Originally posted 09/04/2008 09:45AM

When it comes to fighting cancer, all women – including celebrities – have got to stick together. That was the message from Kelly Ripa Wednesday, as she hosted an event to kick off Ovarian Cancer Month.

"A friend was diagnosed [with the disease] and I wanted to learn more about early detection," she told PEOPLE at the Electrolux-sponsored fund-raiser. "It's my mission to get the word out."

Ripa also took the opportunity to praise Christina Applegate, who has been public about her battle with breast cancer and recent double mastectomy.

"It takes a lot of courage to come forward and help other women and to get ahead of [the disease] like that," Ripa said of the Samantha Who? star. "It really made me call my doctor to get tested."
Liz McNeil

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Olivia Newton-John: Get Well Soon, Christina Applegate

Health

Olivia Newton-John: Get Well Soon, Christina Applegate

Originally posted 08/25/2008 01:35PM

Olivia Newton-John, a breast-cancer survivor who feels "an instant rapport" with others who have the disease, says she is thinking of Christina Applegate and planning to connect with the Samantha Who? star during her time of recovery.

"I haven't met her yet, but I've always liked her and admired her as an actress and would like to just say 'Hey,' so I will," Newton-John told PEOPLE at Project Angel Food's Angel Awards in Los Angeles on Saturday.

Breast-cancer survivors form a kind of sisterhood, says Newton-John, 59, who was diagnosed with the disease in 1992. Asked how her battle and recovery have helped her connect with strangers who have the disease, she replied, "We're not strangers, and particularly if you've been through something like this. I feel connected.

"You understand where they've been. There's that compassion, that connection with someone. So, I feel very lucky that I'm here. I feel lucky that I can pass on the message that I am here."

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