10:21 AM EDT 04/26/2015

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Patrick Dempsey

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Patrick Dempsey: It's Been An Incredible 11 Years on Grey's Anatomy | Patrick Dempsey

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Patrick Dempsey: It's Been An Incredible 11 Years on Grey's Anatomy

Originally posted 04/24/2015 07:30PM

A day after breaking their hearts, Patrick Dempsey thanked Grey's Anatomy fans for their support for more than a decade.

"I want to thank all the fans, what an incredible 11 yrs, I love you all," Dempsey, 49, Tweeted on Friday.

In a shocking twist, his character Dr. Derek Shepherd got killed off in this week's episode, struck by a truck just after saving strangers from an earlier car wreck.

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See Which Longtime Grey's Anatomy Actor Commented on Patrick Dempsey's Departure – and Who Didn't | Patrick Dempsey

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Grey's Anatomy Star Chandra Wilson: Patrick Dempsey Will Always Be 'McDreamy'

Originally posted 04/24/2015 04:50PM

Patrick Dempsey played an integral role in the success of Grey's Anatomy, yet the only thing more stunning than his surprise death Thursday was the way he went out: with absolutely little to no fanfare or statements from fellow cast members.

Dempsey told Entertainment Weekly in an exclusive interview that his final day on the drama's Los Angeles set was "very quiet. It was raining, which was really touching." None of his costars came to the set to say goodbye before he walked alone to his car and drove home.

While he said that he's leaving the show on good terms with his fellow actors, star Ellen Pompeo (Meredith Grey) and Grey's other longtime stars like Justin Chambers (Alex Karev) were not available to comment to EW about Dempsey's departure.

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Patrick Dempsey's 10 McDreamiest Moments on Grey's Anatomy | Patrick Dempsey

Grey's Anatomy

Patrick Dempsey's 10 McDreamiest Moments on Grey's Anatomy

Originally posted 04/24/2015 12:05PM

As we say goodbye to Patrick Dempsey's dreamy doctor alter ego, Derek Shepherd, we're looking back on the 10 best moments that earned him his famous moniker.

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What's Next for Grey's Anatomy's Patrick Dempsey? | Patrick Dempsey

Grey's Anatomy

What's Next for Grey's Anatomy's Patrick Dempsey?

Originally posted 04/24/2015 10:00AM

Just because he's no longer McDreamy doesn't mean we've seen the last of Patrick Dempsey.

After 11 seasons on Grey's Anatomy, the man known to millions as Dr. Derek Shepherd has hung up his scrubs and moved on to new projects.

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Credit: Bob D'Amico/ABC
Let's All Take a Breath and Process What Happened on Grey's Anatomy | Patrick Dempsey

Grey's Anatomy

Grey's Anatomy Recap: What Happened to Derek Shepherd?

Originally posted 04/24/2015 06:55AM

Let's go back to a happier time, a time before Grey's Anatomy aired on Thursday night.

You with us? Okay.

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R.I.P. McDreamy: Twitter Reacts to Grey's Anatomy Shocker | Patrick Dempsey

R.I.P. McDreamy: Twitter Reacts to Grey's Anatomy Shocker

Originally posted 04/23/2015 10:45PM

On Grey's Anatomy, it's usually "a beautiful day to save lives" – sadly, for one major character, however, Thursday night wasn't one of them.

Dr. Derek "McDreamy" Shepherd (Patrick Dempsey), one of the ABC drama's original cast members, said goodbye during the emotional episode, titled "How to Save a Life," after the show's soundtrack mainstay by The Fray.

After heroically saving the lives of a family during a car accident, McDreamy is then T-boned by a truck as he's driving away from the scene. Derek narrates the attempts to save his life, highlighting the mistakes made by his ill-prepared surgeons, before finally being declared brain dead. His wife, Dr. Meredith Grey (Ellen Pompeo) tearfully pulls the plug.

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FROM EW: Shonda Rhimes Gives Statement on Killing Off Grey's Anatomy Star

FROM EW: Shonda Rhimes Gives Statement on Killing Off Grey's Anatomy Star

Originally posted 04/23/2015 10:15PM

"I never imagined saying goodbye," Rhimes said in a statement to EW

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Dr. Derek Shepherd Has Died | Patrick Dempsey

Dr. Derek Shepherd Has Died

Originally posted 04/23/2015 09:45PM

World-renowned brain surgeon Derek Shepherd has died.

The talented doctor, whose car was broadsided after he helped to rescue victims of another accident, died Thursday shortly after doctors failed to properly diagnose the extent of his injuries.

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Credit: Charley Gallay/Getty
FROM EW: Grey's Anatomy Star Patrick Dempsey on Tonight's Shocking Twist | Patrick Dempsey

FROM EW: Grey's Anatomy Star Patrick Dempsey on Tonight's Shocking Twist

Originally posted 04/23/2015 09:35PM

The actor talks to EW about Thursday night's episode

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Credit: Danny Feld/ABC/Getty
McDreamy Is Dead! Patrick Dempsey Killed off Grey's Anatomy | Patrick Dempsey

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McDreamy Is Dead! Patrick Dempsey Killed off Grey's Anatomy

Originally posted 04/23/2015 09:00PM

Did that really just happen on Grey's Anatomy?

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