11/18/2009 AT 08:00 AM EST
Break out the Bordeaux, the whoopee cushions and the bangin' Keith Richards guitar solos, because the 2009 Sexiest Man Alive party
is officially under way. Bringing the fun with him wherever he goes – whether it's onscreen in fizzy roles like Captain Jack Sparrow in the Pirates of the Caribbean
franchise or at home with his family on their private Bahamian island – is just one reason why Johnny Depp
, who also scored the honor in 2003, has joined an elite club of two-time SMA title holders (only Brad Pitt
and George Clooney
have matched the feat). At 46, the father of two still reigns as Hollywood's most irresistible iconoclast; as one-of-a-kind as his beloved 15-year-old boots and as smoldering as his favorite Cuban cigars.
"Johnny Depp has magical powers. He's unlike anyone else,” says actress Isla Fisher, who's married to Sacha Baron Cohen. "He’s funny, generous and clever. It’s just a shame he’s so hard on the eyes."
For much more on Depp and 109 other sexy stars, pick up the latest issue of PEOPLE, on stands now.