The royal house said the prince, known as Friso, died of complications from the accident, without giving more details. It said he had never regained more than "minimal consciousness."
Friso was struck by an avalanche while skiing off-trail in Lech, Austria, on Feb. 17, 2012, and was buried until rescuers pulled him from the snow, unconscious, 20 minutes later. He was resuscitated at the scene and flown to a hospital, but remained in coma for months.
Until the dramatic incidents in Lech, Friso, the second of the former Queen Beatrix's three sons, had sometimes been known as "Prince Brilliant." He studied at UC Berkeley, the Technical University of Delft and Erasmus University at Rotterdam, graduating from the Dutch universities cum laude with degrees in engineering and economics. He later earned an MBA at France's prestigious INSEAD school of business.
Gave Up Claim to the ThroneBut the central event of his life as a royal came when he gave up his claim to the throne in order to marry Dutchwoman Mabel Wisse Smit, in a wedding not sanctioned by the government.The pair had announced their relationship in 2002 and got engaged in 2003.
Wisse Smit worked for George Soros's Open Society Institute and was long seen by the queen as an ideal daughter-in-law. But during her vetting to join the royal house, the pair decided not to disclose the full extent of a friendship she had had while she was a college student.
The friend in question: drug baron Klaas Bruinsma, who later became one of the country's most infamous crime lords and was slain in a gangland killing. Wisse Smit denies ever having had any romantic involvement with Bruinsma, and says she hadn't understood who he was at the time.
Friso and Mabel decided to marry without seeking parliamentary approval, knowing the decision meant Friso would be cut from the royal house and line of succession. They were still considered members of the royal family, and bore the honorific titles of Prince and Princess of Orange-Nassau.
After the affair – dubbed "Mablegate" in the Dutch press, because the "cover-up" did most of the damage – Friso seemed relieved at the certainty he would never be called upon to assume the throne.
"I'm not planning to return to the Netherlands any time soon," he said in a televised statement. "I am planning to remain available for my mother or brother if it's needed, for supporting roles."
Friso had spent most of his life as second in line for the throne behind Willem-Alexander, but never appeared enthusiastic. As a child he was filmed saying "you can hit Alex, but not so hard he gets killed, because then I'd have to be king."
After graduating from college, he worked as a consultant for McKinsey & Co in Amsterdam. He went on to work for Goldman Sachs' investment banking arm in London, eventually becoming vice president. After his marriage, Friso served on various supervisory boards, worked for charitable organizations and helped found a low-cost airline. In 2011 he left a position as managing director at investment firm Wolfensohn & Company to became the chief financial officer of Urenco, the European uranium enrichment consortium.
One of Friso's most sympathetic moments in the public eye came shortly after the death of his father, Prince Claus: it fell to Friso to escort his mother at the funeral ceremony. He supported her in a long, stately walk to her seat as she leaned heavily on his arm, deep in grief.
Friso is survived by Princess Mabel, and two daughters, Luana and Zaria.