The royals will hear multiple compelling stories first-hand on March 10 – among them that of Jonny Benjamin, whose life was saved by a stranger in 2008 as he contemplated suicide.
After receiving help, Benjamin launched the social media campaign #FindMike, together with the charity Rethink Mental Illness, to find his savior.
The campaign succeeded and Benjamin was reunited with, not a Mike, but Neil Laybourn.
William, 33, and Kate, 34, will head to St. Thomas's hospital, on the south bank of the River Thames in London, where Benjamin was initially sent for treatment.
Then, back at their offices at Kensington Palace, the couple will watch part of a documentary about Benjamin's experience, along with a group of about 20 children from a south London school. Later, the royals will participate in a private discussion with a group who have been bereaved in various ways by suicide.
William's focus on the mental illnesses facing young men is partly inspired by witnessing their consequences during his work as an air ambulance pilot.
In his first months working with the East Anglian Air Ambulance last summer, William's crew was called out to suicide cases involving young men. They failed in at least one of those cases, despite the efforts of the medical team.
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The visit on March 10 with Kate comes as the couple and William's brother Prince Harry are spearheading a three-pronged approach to tackling mental illness: Kate is looking at where children can be affected, Harry at the issues facing service members and William is focusing on vulnerable young men and adults.
A Kensington Palace spokesman tells PEOPLE, "The Duke and Duchess of Cambridge and Prince Harry are continuing to work with mental health experts and charities to help raise awareness of a variety of issues within the sector."