Accepting the award for her portrayal of Rachel Berry on Glee, she tearfully dedicated her win to Monteith, who died from a a lethal combination of alcohol and heroin.
"I promise that with your love, we're going to get through this together," Michele, 26, told the audience gathered at Los Angeles's Gibson Amphitheatre. "He was very special to me and also to the world, and we were very lucky to witness his incredible talent, his handsome smile and his beautiful, beautiful heart.
"So whether you knew him personally or just as [his character] Finn Hudson, Cory reached out, and he became a part of all of our hearts and that's where he'll stay forever."
Moments earlier, her Glee cast mates – who are back to work on the show's fifth season after paying tribute to the late actor on the Paramount studio lot – accepted the award for Choice Comedy Show.
"Cory was like a brother to us," Amber Riley told the audience. "He was always ready to sign an autograph or take a picture with a fan, and he loves you Gleeks."
Added costar Jenna Ushkowitz: "We know that Cory would have wanted us to dedicate this award to you guys."
Fans of Monteith may make donations in his name to three charities that were especially important to him: Project Limelight Society, which exposes youth living in Vancouver's Downtown Eastside to the arts; Virgin Unite, founded to support entrepreneurial efforts to better the world; and