Over a week since the news of Barrymore's divorce, it was announced on Monday that the actress will be guest starring in season two of Kargman's Bravo scripted series Odd Mom Out.
Barrymore, 41, will portray Meredith, an irreverent neighbor who survives a historic blizzard with Jill and Andy. Also coming to the Upper East Side is actress Blythe Danner, who will be playing Jill's mother, Sarah Kaplan.
In the sophomore season of Odd Mom Out, fans will learn more about Jill's work life as she returns to her job at a fashion magazine while Andy becomes Mr. Mom and realizes that parenting three kids is much harder than he expected.
Earlier this month, Barrymore and Kopelman, 38, publicly confirmed they were ending their marriage after almost four years.
"Sadly our family is separating legally, although we do not feel this takes away from us being a family," the pair said in their statement. "Divorce might make one feel like a failure, but eventually you start to find grace in the idea that life goes on. Our children are our universe, and we look forward to living the rest of our lives with them as the first priority."
Barrymore and Kopelman married in 2012 after dating for one year. Together they have two children: Olive, 3, and Frankie, 23 months.
Odd Mom Out returns June 20.