Following Tuesday night's primary in Indiana, the GOP front-runner was named the presumptive nominee after Texas Senator Ted Cruz announced that he was suspending his campaign.
"Donald Trump will be presumptive GOP nominee, we all need to unite and focus on defeating @HillaryClinton #NeverClinton," Republican Party chairman Reince Priebus tweeted.
Although, Trump and Cruz were far from cordial opponents throughout the race, the billionaire businessman said what Cruz did was a "brave thing to do because we want to bring unity."
While Cruz revealed he was leaving the race as there no longer seemed to be a "viable" path to the White House, Ohio Governor John Kasich has not announced the end of his campaign. However, even with Kasich still in the race, Trump sits in a comfortable position to officially take the nomination if he secures the required 1,237 delegates needed to win his party.
"Tonight's results are not going to alter Gov. Kasich's campaign plans," Kasich's chief strategist John Weaver said, according to CNN. "Our strategy has been and continues to be one that involves winning the nomination at an open convention."
While Kasich's camp continues to be optimistic, Democratic nominee Hillary Clinton's campaign – which also took a blow to her campaign when Senator Bernie Sanders won Indiana – released a statement, condemning the announcement that Trump is the Republican party's presumptive nominee.
"Fundamentally, our next president will need to do two things: keep our nation safe in a dangerous world and help working families get ahead here at home," the statement, obtained by PEOPLE, read. "Donald Trump is not prepared to do either. Throughout his campaign, Donald Trump has demonstrated that he's too divisive and lacks the temperament to lead our nation and the free world.
"With so much as stake, Donald Trump is simply too big of a risk. Hillary Clinton has proven that she has the strength to keep us safe in an uncertain world and a lifelong record of fighting to break down the barriers – economic and social – that hold working families back. While Donald Trump seeks to bully and divide Americans, Hillary Clinton will unite us to create an economy that works for everyone."
While Trump ignored any criticism, saying during his victory speech at Trump tower, "We're going to win in November", he faced backlash from another opponent in the form anti-Trump adds that the Progressive Change Campaign Committee has released in an accelerated campaign against Trump.
According to a press release from the PCCC, the ads will highlight Trump's "hate-mongering, his disrespect for women, and his belief that American wages are 'too high'."
Never ever ever Trump. Simple as that.— Tim Miller (@Timodc) May 4, 2016
"We have already begun running ads across the nation hitting Donald Trump – defining him early and moving the debate to our turf. This is key to winning."
WATCH: Voters React to Ted Cruz Dropping Out of the Presidential Race
Other opponents of the real estate mogul quickly vocalized their opinions, including former adviser toJeb Bush Tim Miller who currently serves as the spokesman for an anti-Trump super-PAC, Our Principles PAC.
"Never ever, ever Trump. Simple as that," Miller tweeted
Despite lots of criticism, the presidential hopeful did find support in Sarah Palin, who has endorsed the former reality star before, but also took to Facebook sharing a video in which she calls for unity "on the road to making America great again."
Trump also spoke about unity on Tuesday night, adding in his speech that his focus is on bringing the Republican Party together after "and amazing evening."