Sexiest Man Alive 2008

PATRICK DEMPSEY

Four seasons into Grey's Anatomy and his Dr. Shepherd can still make EKGs go haywire, but in real life "defining romance is very tricky," says Dempsey, 41. The father to 9-month-old twins Darby and Sullivan and daughter Talula, 5, has been married to wife Jillian for eight years. "It's not just candles and flowers." The secret to keeping the spark alive? The eyes. Hers. "I was always taken by them," he says. "They're warm, sparkly eyes. That's the most beautiful part of someone."