Most Beautiful 2009

CHRISTINA APPLEGATE

This year's Most Beautiful star admits that after being diagnosed with breast cancer last March, she had "a rollercoaster of emotions, but there was a calm about what I had to do." The Samantha Who? actress, 37, underwent a double mastectomy, followed by reconstructive surgery. "It's a decision that you made to save your life," she says, noting one positive effect: "I don't have to wear a bra! They don't hang down to my knees like they did before. And the gals look good in tank tops."