Sexiest Man Alive 2011

Sexiest Man Alive: Who Could Be Next?

Tom Cruise, Johnny Depp, Brad Pitt – who could inherit the crown from these past PEOPLE cover stars?

  • SMA '86: MARKSEXY-IN-WAITING: PATRICK
 photo | Mark Harmon, Patrick Dempsey

Credit: Anne Knudsen/Sygma/Corbis; Jason LaVeris/FilmMagic

Updated: Friday Nov 12, 2010 | 05:00 PM EST By: Kiran Hefa & Kate Hogan

SMA '86: MARK
SEXY-IN-WAITING: PATRICK

Nicknamed "Charmin' Harmon," St. Elsewhere star Mark Harmon joked to PEOPLE that one of the perks of his job was, "Women would come up to me and show me their breasts and ask for my opinion." Today's Dr. McDreamy Patrick Dempsey has an equally enthusiastic but tamer fan base, among them daughter Talula. "One day [she] said, 'You're very handsome, Poppy,'" Dempsey told PEOPLE.