You Had Me at Hello
In a surprise wedding, just four months after meeting, Zellweger weds country star Kenny Chesney in the U.S. Virgin Islands. The bride wears a white Caroline Herrera dress, while the groom dons a black cowboy hat. One of Cheney's biggest hits, "You Had Me from Hello," was inspired by the famous line she uttered in Jerry Maguire.
The highly anticipated Cinderella Man, in which Zellweger plays opposite fellow Oscar-winner Russell Crowe, makes a disappointing $61.6 million at the box office. Critics still praise Zellweger for her portrayal of champion boxer James Braddock's long suffering wife.
Hello and Goodbye
A mere four months after their quickie wedding, Zellweger files annulment papers, citing "fraud" as the reason for her split from Chesney. The two release a statement saying "the miscommunication of the objective of their marriage at the start is the only reason for this annulment."
Renée Hops Back on Screen
In her first role since her split from Chesney, Zellweger takes on the title role in Miss Potter, where she reunites with Down with Love costar Ewan McGregor to play Peter Rabbit author Beatrix Potter. She tells Life that working on the film helped her get through her "devastating" split from Chesney. Her performance earns her a Golden Globe nod for Best Actress.
Reuniting with Clooney
After starring in Jerry Seinfeld's animated feature Bee Movie, Zellweger appears on the cover of W with George Clooney. Besides promoting their 2008 romantic comedy Leatherheads (which Clooney also directed), the old friends poke fun at their alleged romantic relationship and their work together.
Renée's New In Town
Zellweger returns to her romantic comedy roots in New In Town, where she plays a corporate go-getter who travels out of her element to a Minnesota town for work. Opposite Harry Connick Jr., the actress says filming in the blistering cold was "highly entertaining and highly educational."
Flying the Coop!
After filming the thriller Case 39, Zellweger gets cozy with costar Bradley Cooper in Barcelona. Though the pair keeps their romance quiet, they're spotted together in Los Angeles and New York. "I can't say enough about her," Cooper gushes of Zellweger. "I just love her. I [loved] coming to work. I love acting with her. I can learn so much from her." After nearly two years together, the couple calls it quits in March 2011.
BIOGRAPHY (top to bottom): NYPP/ZUMA; Carolyn Snell/WireImage; Universal/Everett; CAROLYN SNELL; Courtesy of W; Splash News Online